Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle
February 2023
New findings led by Josh Shin in Nature Metabolism. Josh identified a novel mechanism that evolved in mammals by which cells sense pyrimidine nucleotide levels. A specific enzyme, CAD, is a gatekeeper for nucleotide synthesis and is controlled by UTP using conserved loop switches in its allosteric domain.
Read More (https://www.nature.com/articles/s42255-023-00735-9)
Lab member Elizabeth Gorodetsky receives NIH Ruth L. Kirschstein National Research Service Award!
March, 2022
Lab member Marte Molenaars receives Human Frontier Science Program Postdoctoral Fellowship!
March 2022
Lab member Marte Molenaars receives EMBO Postdoctoral Fellowship!
December 2021
Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5
May 2021
New publication led by lab member Erdem Terzi in the journal Science Advances. Cells must carefully manage iron to prevent oxidative damage and cell death. A specific cellular component, IRP2, regulates iron levels in a way that may be dysregulated in an inherited neurodegenerative disease.
Read More (https://doi.org/10.1126/sciadv.abg4302)
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that can be Exploited by Targeting DNA Polymerase Epsilon
November 2020
New publication led by lab member Vlad Sviderskiy in the journal Molecular Cell. A difficult to treat type of breast cancer, basal-like, is unusually sensitive to inhibition of a gene involved in DNA duplication, POLE1. Cancer promoting changes typically present in this tumor type were identified as factors that cause sensitivity to POLE1 inhibition.
Read More (https://www.sciencedirect.com/science/article/pii/S1097276520307231)
Summer Student Takaharu Araki named 2020 Regeneron STS Scholar
January, 2020
Taka's investigated the impact of oxygen and mTORC1 activation on central carbon metabolism under the mentorship of Jong Shin.
Read More (https://www.societyforscience.org/regeneron-sts/2020-scholars/)
Possemato Lab Receives American Cancer Society Research Scholar Grant
January, 2020
Dr. Possemato receives the 2019 Above and Beyond Mentorship Award from the NYU Students Advocating for Science, Education, and Medicine
October, 2019
This student led award recognized "a mentor at the NYU School of Medicine who creates an excellent experience for trainees".
Read More (https://med.nyu.edu/pathology/sites/default/files/pathology/photos/news-Possemato-MentorShipAward.pdf)
Lab member Vlad Sviderskiy receives NIH Ruth L. Kirschstein National Research Service Award!
April, 2018
Lab member Vlad Sviderskiy selected to attend Lindau Nobel Laureate Meeting
March, 2018
Vlad, an MD/PhD student, was selected in a competition to attend this prestigious meeting in Lindau, Germany, where he will have the opportunity meet current and past Nobel Laureates. Perhaps someday they will be his peers!
Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs
February, 2018
New publication by lab members Minwoo Nam, Daniel McLaughlin, and Denise Minton in the journal Molecular Cell. Serine catabolic enzyme SHMT2 contributes one carbon units required for the production of mitochondrial initiator tRNA formylation. SHMT2 loss impacts mitochondrial translation, depleting mitochondrially encoded proteins and decreasing respiration.
Press Release: New Way to Target Lung Tumors Unveiled Through Creative Research
February 2, 2018
A protein’s role in helping such cancers respond to their environment may be a key to innovative therapies
Richard Possemato named a 2018 AACR NextGen Star
January, 2018
NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells From Elevated Oxygen Levels and Ferroptosis
November, 2017
New publication by lab members Samantha Alvarez, Vlad Sviderskiy, and Erdem Terzi in the journal Nature. Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect cells from oxidative damage induced cell death
Richard Possemato named a 2016 Pew-Stewart Scholar
June, 2016
A new group of young researchers is blazing a path of groundbreaking science. On June 9, The Pew Charitable Trusts announced the 2016 class of Pew biomedical scholars, Latin American fellows and Pew-Stewart Scholars for Cancer Research.
Possemato Lab awarded a 2015 Susan G. Komen Career Catalyst Grant
April, 2015
Dr. Richard Possemato joins the Pathology Department at the NYU School of Medicine as an Assistant Professor
September 27, 2014
Press Release: How diabetes drugs may work against cancer
September 27, 2014
Dr. Richard Possemato receives NIH K99/R00 Pathway to Independence Award
September 27, 2014
Dr. Richard Possemato wins Margaret and Herman Sokol Post-doctoral Award, Whitehead Institute
September 27, 2014
Press Release: Key metabolic pathway implicated in intractable form of breast cancer
September 27, 2014
