Possemato Lab
Diagram of SHMT2-driven mitochondrial translation initiation
Model figure on POLE and basal-like breast cancer
Figure on NFS1 and iron-sulfur cluster metabolism
Figure on apoptotic pathways and pyrimidine restriction
Figure on pyrimidine sensing by the enzyme CAD
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Metabolic pathways altered in the transformed state

Our laboratory focuses on identifying metabolic pathways that are altered in the transformed state, understanding how those pathways support transformation, and investigating the environmental, genetic and epigenetic contexts in which such pathways act.

550 First Avenue, Smilow 611, New York, NY 10016

Iron-sulfur metabolism TNBC / POLE Tumor-nutrient interactions

Selected discoveries

Nature · Sci Adv
Iron-sulfur clusters and iron sensing

NFS1 protects cells from oxidative stress and ferroptosis.

Molecular Cell
A liability in triple-negative breast cancer

POLE suppression selectively targets basal-like tumors.

Nature Metabolism
Glucose shapes chemotherapy response

Low glucose blunts apoptosis from pyrimidine restriction.

How we work

01
Screen
Nutrient-limited genetic screens
02
Validate
Cell and mouse models
03
Mechanism
Biochemistry, structure
04
Translate
Therapeutic targets