Lab news

Possemato and Krogsgaard Lab team up for Pew Biomedical Research Collaboration

We are investigating how metabolic limitation impairs effector T cell function and identify strategies to enhance T cell performance in metabolically hostile environments such as triple-negative breast cancer tumors. Read more →

How Some Cancer Cells Survive Chemotherapy

Chemotherapy drugs can kill cancer cells by halting DNA replication, but a glucose-depleted environment can help cancer cells overcome this effect and resist death. Read more →

This popular science article covers Minwoo’s manuscript, “Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition Read more →

Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle

New findings led by Josh Shin in Nature Metabolism. Josh identified a novel mechanism that evolved in mammals by which cells sense pyrimidine nucleotide levels. A specific enzyme, CAD, is a gatekeeper for nucleotide synthesis and is controlled by UTP using conserved loop switches in its allosteric domain. Read more →

Lab member Elizabeth Gorodetsky receives NIH Ruth L. Kirschstein National Research Service Award!

Lab member Marte Molenaars receives Human Frontier Science Program Postdoctoral Fellowship!

Lab member Marte Molenaars receives EMBO Postdoctoral Fellowship!

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

New publication led by lab member Erdem Terzi in the journal Science Advances. Cells must carefully manage iron to prevent oxidative damage and cell death. A specific cellular component, IRP2, regulates iron levels in a way that may be dysregulated in an inherited neurodegenerative disease. Read more →

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that can be Exploited by Targeting DNA Polymerase Epsilon

New publication led by lab member Vlad Sviderskiy in the journal Molecular Cell. A difficult to treat type of breast cancer, basal-like, is unusually sensitive to inhibition of a gene involved in DNA duplication, POLE1. Cancer promoting changes typically present in this tumor type were identified as factors that cause sensitivity to POLE1 inhibition. Read more →

Summer Student Takaharu Araki named 2020 Regeneron STS Scholar

Taka's investigated the impact of oxygen and mTORC1 activation on central carbon metabolism under the mentorship of Jong Shin. Read more →

Possemato Lab Receives American Cancer Society Research Scholar Grant

Dr. Possemato receives the 2019 Above and Beyond Mentorship Award from the NYU Students Advocating for Science, Education, and Medicine

This student led award recognized "a mentor at the NYU School of Medicine who creates an excellent experience for trainees". Read more →

Lab member Vlad Sviderskiy receives NIH Ruth L. Kirschstein National Research Service Award!

Lab member Vlad Sviderskiy selected to attend Lindau Nobel Laureate Meeting

Vlad, an MD/PhD student, was selected in a competition to attend this prestigious meeting in Lindau, Germany, where he will have the opportunity meet current and past Nobel Laureates. Perhaps someday they will be his peers! Read more →

Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs

New publication by lab members Minwoo Nam, Daniel McLaughlin, and Denise Minton in the journal Molecular Cell. Serine catabolic enzyme SHMT2 contributes one carbon units required for the production of mitochondrial initiator tRNA formylation. SHMT2 loss impacts mitochondrial translation, depleting mitochondrially encoded proteins and decreasing respiration. Read more →

Press Release: New Way to Target Lung Tumors Unveiled Through Creative Research

A protein’s role in helping such cancers respond to their environment may be a key to innovative therapies Read more →

Richard Possemato named a 2018 AACR NextGen Star

Read more →

NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells From Elevated Oxygen Levels and Ferroptosis

New publication by lab members Samantha Alvarez, Vlad Sviderskiy, and Erdem Terzi in the journal Nature. Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect cells from oxidative damage induced cell death Read more →

Richard Possemato named a 2016 Pew-Stewart Scholar

A new group of young researchers is blazing a path of groundbreaking science. On June 9, The Pew Charitable Trusts announced the 2016 class of Pew biomedical scholars, Latin American fellows and Pew-Stewart Scholars for Cancer Research. Read more →

Possemato Lab awarded a 2015 Susan G. Komen Career Catalyst Grant

Dr. Richard Possemato joins the Pathology Department at the NYU School of Medicine as an Assistant Professor

Press Release: How diabetes drugs may work against cancer

Read more →

Dr. Richard Possemato receives NIH K99/R00 Pathway to Independence Award

Dr. Richard Possemato wins Margaret and Herman Sokol Post-doctoral Award, Whitehead Institute

Press Release: Key metabolic pathway implicated in intractable form of breast cancer

Read more →